藻菌共生系统去除污水中抗生素的研究进展

doi:10.19965/j.cnki.iwt.2025-0382

摘要/Abstract

摘要：

抗生素的广泛使用及传统污水处理手段对抗生素的去除效率偏低导致全球范围内的水环境中均有不同浓度的抗生素检出。藻菌共生系统是一种可持续的废水处理方法，具有高效去除抗生素、减少抗性基因增殖和收获生物质等优势。综述了藻菌共生系统的结构及特性，总结了抗生素对藻菌共生系统的影响；综合微藻与细菌对抗生素的去除机制，归纳出藻菌共生系统去除抗生素的可能途径；分析讨论了抗生素种类及浓度、生物组成、光照、温度、pH等因素对抗生素去除途径及效率的影响；介绍了现有的基于藻菌共生系统去除抗生素的新技术。在此基础上，提出了未来需要深入研究的方向，如藻菌分子层面上的相互作用、物种的合理组合及复杂水环境中抗生素对藻菌共生系统的影响等。

关键词: 藻菌共生系统, 抗生素, 去除途径, 影响因素

Abstract:

The widespread use of antibiotics, coupled with the inadequate removal efficiency of these substances by traditional wastewater treatment methods, has resulted in the global presence of antibiotics at varying concentrations in aquatic ecosystems. The microalgae-bacteria consortia presents a sustainable approach to wastewater treatment,characterized by its high removal capacity, suppression of resistance gene proliferation, and the potential for biomass recovery. This paper provided a comprehensive review of the structure and characteristics of the microalgae-bacteria consortia, while also summarized the effects of antibiotics on this system. The mechanisms of antibiotic removal by microalgae and bacteria were analyzed, and the potential pathways for antibiotic degradation within the symbiotic framework were presented. Furthermore, this paper critically examined the influence of various factors,including the type and concentration of antibiotics, the biochemical composition of the microalgae-bacteria consortia,illumination, temperature, as well as pH on the efficiency and pathways of antibiotic removal. Additionally, innovative microalgae-bacteria consortia currently in development for the purpose of antibiotic remediation was highlighted. Based on the findings, future research directions were proposed, which included investigating the molecular interactions between microalgae and bacteria, optimizing species combinations, and assessing the impact of antibiotics on the microalgae-bacteria consortia within complex aquatic environments.

Key words: microalgae-bacteria consortia, antibiotics, removal pathways, influencing factors

中图分类号:

X703

彭悦, 李茹莹, 赵恰. 藻菌共生系统去除污水中抗生素的研究进展[J]. 工业水处理, 2026, 46(4): 1-16.

Yue PENG, Ruying LI, Qia ZHAO. Advances in microalgae-bacteria consortia for removal of antibiotic from wastewater[J]. Industrial Water Treatment, 2026, 46(4): 1-16.

https://gyscl.magtechjournal.com/CN/Y2026/V46/I4/1

图/表 3

参考文献 95

[1]	卫承芳，李佳乐，孙占学，等. 水-土壤环境中抗生素污染现状及吸附行为研究进展［J］. 生态毒理学报，2022，17（3）：385-399.
	WEI Chengfang， LI Jiale， SUN Zhanxue，et al. Research progress of antibiotic pollution and adsorption behavior in water-soil environment［J］. Asian Journal of Ecotoxicology，2022，17（3）：385-399.
[2]	YE Fuzhu， CHU Kejian， HUA Zulin，et al. Distribution and fate of antibiotics in water-sediment-biofilm phases and their potential risks in urban lakes within a large-scale city in eastern China［J］. Journal of Hazardous Materials，2025，496：139421. doi:10.1016/j.jhazmat.2025.139421
[3]	MURRAY C J L， IKUTA K S， SHARARA F，et al. Global burden of bacterial antimicrobial resistance in 2019：A systematic analysis［J］. The Lancet，2022，399（10325）：629-655.
[4]	ZHANG Xuwang， LI Menglong， XIAO Yang，et al. Metagenomics reveals combined effects of microplastics and antibiotics on microbial community structure and function in coastal sediments［J］. Marine Pollution Bulletin，2025，218：118153.
[5]	SHARMA M， SALAMA E S， ZHANG Peng，et al. Microalgae-assisted microbial fuel cells for electricity generation coupled with wastewater treatment：Biotechnological perspective［J］. Journal of Water Process Engineering，2022，49：102966. doi:10.1016/j.jwpe.2022.102966
[6]	WANG Yue， NING Weihao， HAN Meina，et al. Algae-mediated bioremediation of ciprofloxacin through a symbiotic microalgae-bacteria consortium［J］. Algal Research，2023，71：103062. doi:10.1016/j.algal.2023.103062
[7]	WANG Jinli， CHEN Xiangnan， SUN Haibo，et al. Accelerated removal and mechanism of tetracycline from water using immobilized bacteria combined with microalgae［J］. Journal of Environmental Chemical Engineering，2025，13（2）：115424. doi:10.1016/j.jece.2025.115424
[8]	SUBIRATS J， PASTOR-LÓPEZ E J， PASCÓ J，et al. Green solutions for treating groundwater polluted with nitrates，pesticides，antibiotics，and antibiotic resistance genes for drinking water production［J］. Journal of Environmental Management，2025，375：124263. doi:10.1016/j.jenvman.2025.124263
[9]	WANG Jingyu， LIU Hongyuan， PENG Mengwen，et al. Amoxicillin degradation and high-value extracellular polymer recovery by algal-bacterial symbiosis systems［J］. Journal of Hazardous Materials，2023，460：132344.
[10]	ZHANG Jingmiao， XIA Ao， YAO Dunxue，et al. Removal of oxytetracycline and ofloxacin in wastewater by microalgae-bacteria symbiosis for bioenergy production［J］. Bioresource Technology，2022，363：127891. doi:10.1016/j.biortech.2022.127891
[11]	EHENEDEN I， WANG Rongchang， CHEN Gaoxiang，et al. Sulfamethoxazole removal and ammonium conversion in microalgae consortium：Physiological responses and microbial community changes［J］. Science of The Total Environment，2024，954：176539.
[12]	ZAMBRANO J， GARCÍA-ENCINA P A， HERNÁNDEZ F，et al. Kinetics of the removal mechanisms of veterinary antibiotics in synthetic wastewater using microalgae-bacteria consortia［J］. Environmental Technology & Innovation，2023，29：103031.
[13]	CHENG Pu， WANG Zhengfang， LU Bei，et al. Effects of mixed LED light wavelengths and strigolactone analog concentrations on integral biogas upgrading and antibiotic removal from piggery wastewater by different microalgae-bacteria-fungi consortia［J］. Algal Research，2024，82：103622.
[14]	SUN Jian， LI Nan， YANG Ping，et al. Simultaneous antibiotic degradation，nitrogen removal and power generation in a microalgae-bacteria powered biofuel cell designed for aquaculture wastewater treatment and energy recovery［J］. International Journal of Hydrogen Energy，2020，45（18）：10871-10881. doi:10.1016/j.ijhydene.2020.02.029
[15]	LI Yonghong， FENG Lifei， LI Guanghua，et al. Removing high strength lincomycin in pharmaceutical wastewater by a bacteria microalgae consortium co-immobilized filter［J］. Bioresource Technology，2025，415：131704. doi:10.1016/j.biortech.2024.131704
[16]	REN Haijing， WANG Rongchang， YING Luyao，et al. Removal of sulfamethoxazole in an algal-bacterial membrane aerated biofilm reactor：Microbial responses and antibiotic resistance genes［J］. Water Research，2025，268：122595.
[17]	ZHANG Jingshen， LI Shuangxi， LU Huiling，et al. Lighting strategy drives removal of ammonia nitrogen and phosphate in microalgae-bacteria consortia under tetracycline hydrochloride exposure［J］. Algal Research，2025，88：103989. doi:10.1016/j.algal.2025.103989
[18]	ZHAO Shasha， QIAN Jin， LU Bianhe，et al. Enhancing treatment performance of Chlorella pyrenoidosa on levofloxacin wastewater through microalgae-bacteria consortia：Mechanistic insights using the transcriptome［J］. Journal of Hazardous Materials，2024，479：135670. doi:10.1016/j.jhazmat.2024.135670
[19]	FAN Yiwei， WANG Hutao， SUN Cheng，et al. Metagenomic and transcriptome elucidating the sulfamethoxazole degradation and metabolism pathways in fermentative bacteria and microalgae coupling system for mariculture wastewater treatment［J］. Chemical Engineering Journal，2023，474：145560. doi:10.1016/j.cej.2023.145560
[20]	YU Ziqi， LIN Guannan， LIU Ying，et al. Treatment of sulfamethoxazole-polluted wastewater coupled to lipid production by cyanobacteria-bacteria consortium in baffled photobioreactor［J］. Journal of Environmental Chemical Engineering，2025，13（3）：116510. doi:10.1016/j.jece.2025.116510
[21]	SILVA RODRIGUES D A DA， CUNHA C C R F DA， PEREIRA A R，et al. Biodegradation of trimethoprim and sulfamethoxazole in secondary effluent by microalgae-bacteria consortium［J］. International Journal of Hygiene and Environmental Health，2025，264：114517. doi:10.1016/j.ijheh.2024.114517
[22]	SERRA V， GAMMUTO L， PETRONI G，et al. Identification of the bacteria associated to the phycosphere of the chlorella-like strain SEC_LI_ChL_1［J］. Algal Research，2022，67：102869.
[23]	PATIDAR S K. Metabolic interactions between microalgae and bacteria：Multifunctional ecological interplay and environmental applications［J］. Algal Research，2025，86：103904.
[24]	APARICIO S， RÍOS-MEJÍA A， GALLARDO-MEJÍAS J P，et al. Microalgae-bacteria consortia dynamics in a long term operated membrane-coupled high-rate algal pond（MHRAP）［J］. Journal of Environmental Management，2024，371：123186.
[25]	ALTIMARI P， DI CAPRIO F， BRASIELLO A，et al. Production of microalgae biomass in a two-stage continuous bioreactor：Control of microalgae-bacteria competition by spatial uncoupling of nitrogen and organic carbon feeding［J］. Chemical Engineering Science，2023，272：118604. doi:10.1016/j.ces.2023.118604
[26]	SEYMOUR J R， AMIN S A， RAINA J B，et al. Zooming in on the phycosphere：The ecological interface for phytoplankton-bacteria relationships［J］. Nature Microbiology，2017，2：17065.
[27]	CAO Yuang， ZHI Suli， PHYU K，et al. Interaction between microalgae and phycosphere bacteria in a binary cultivation system-based dairy farm wastewater treatment［J］. Bioresource Technology，2024，409：131248. doi:10.1016/j.biortech.2024.131248
[28]	ABURAI N， TSUKAGOSHI T， SEKIGUCHI S，et al. Mutual supply of carbon and nitrogen sources in the co-culture of aerial microalgae and nitrogen-fixing bacteria［J］. Algal Research，2023，70：103001. doi:10.1016/j.algal.2023.103001
[29]	JI Xiyan， CHEN Xinying， LI Huimin，et al. Effects of carboxyl single-walled carbon nanotubes on synthetic wastewater nutrient removal by an algal-bacterial consortium：Regulation and interaction［J］. Science of the Total Environment，2019，685：997-1005.
[30]	LIU Qixin， FENG Xuan， SHENG Zhiya，et al. Enhanced wastewater treatment performance by understanding the interaction between algae and bacteria based on quorum sensing［J］. Bioresource Technology，2022，354：127161.
[31]	SAIKIA B， BHATTACHARYYA A， CHANDRA BORO R，et al. Bioprospecting of bacterial endophytes from Solanum pimpinellifolium with antifungal activity against Fusarium oxysporum f. sp. lycopersici causing vascular wilt［J］. Physiological and Molecular Plant Pathology，2025，136：102566. doi:10.1016/j.pmpp.2025.102566
[32]	AMIN S A， HMELO L R， VAN TOL H M，et al. Interaction and signalling between a cosmopolitan phytoplankton and associated bacteria［J］. Nature，2015，522（7554）：98-101.
[33]	SHADAB M， BHATTI N，AIN Q，et al. Allelopathy for the sustainable management of agricultural pests：Appraisal of major allelochemicals and mechanisms underlying their actions［J］. South African Journal of Botany，2024，175：496-513.
[34]	CHEN Qi， ZHU Bo， SUN Dong，et al. The effect of protocatechuic acid on the phycosphere in harmful algal bloom species Scrippsiella trochoidea ［J］. Aquatic Toxicology，2020，227：105591. doi:10.1016/j.aquatox.2020.105591
[35]	BOO A， LEDESMA AMARO R， STAN G B. Quorum sensing in synthetic biology：A review［J］. Current Opinion in Systems Biology，2021，28：100378. doi:10.1016/j.coisb.2021.100378
[36]	DUBERN J F， DIGGLE S P. Quorum sensing by 2-alkyl-4-quinolones in Pseudomonas aeruginosa and other bacterial species［J］. Molecular BioSystems，2008，4（9）：882-888. doi:10.1039/b803796p
[37]	GALLOWAY W R J D， HODGKINSON J T， BOWDEN S D，et al. Quorum sensing in gram-negative bacteria：Small-molecule modulation of AHL and AI-2 quorum sensing pathways［J］. Chemical Reviews，2011，111（1）：28-67. doi:10.1021/cr100109t
[38]	HENGGE R， GRÜNDLING A， JENAL U，et al. Bacterial signal transduction by cyclic di-GMP and other nucleotide second messengers［J］. Journal of Bacteriology，2016，198（1）：15-26. doi:10.1128/jb.00331-15
[39]	ZHANG Chaofan， LI Qingcheng， FU Liang，et al. Quorum sensing molecules in activated sludge could trigger microalgae lipid synthesis［J］. Bioresource Technology，2018，263：576-582. doi:10.1016/j.biortech.2018.05.045
[40]	LIU Zuocheng， ZENG Ting， WANG Jinlong，et al. AHL-mediated quorum sensing drives microbial community succession and metabolic pathway in algal-bacterial biofilm system［J］. Water Research，2025，282：123702. doi:10.1016/j.watres.2025.123702
[41]	杨淋，王帅，迟旭辉，等. 群体感应和群体猝灭在藻菌互作中的功能研究进展［J］. 微生物学通报，2024，51（5）：1441-1459.
	YANG Lin， WANG Shuai， CHI Xuhui，et al. Research progress in quorum sensing and quorum quenching in the interaction between microalgae and bacteria［J］. Microbiology China，2024，51（5）：1441-1459.
[42]	PARK H，NAM J， KIM T S，et al. Enzymatic quorum quenching for enhanced production of microalgae biomass in membrane-based floating photobioreactor［J］. Journal of Environmental Chemical Engineering，2025，13（5）：117382. doi:10.1016/j.jece.2025.117382
[43]	HU Hao， WU Dandan， YU Li，et al. Pollutants removal，microbial community shift and oleic acid production in symbiotic microalgae-bacteria system［J］. Bioresource Technology，2023，370：128535.
[44]	SAMO T J， KIMBREL J A， NILSON D J，et al. Attachment between heterotrophic bacteria and microalgae influences symbiotic microscale interactions［J］. Environmental Microbiology，2018，20（12）：4385-4400.
[45]	YAN Hongbin， LU Rumeng， LIU Yuhuan，et al. Development of microalgae-bacteria symbiosis system for enhanced treatment of biogas slurry［J］. Bioresource Technology，2022，354：127187. doi:10.1016/j.biortech.2022.127187
[46]	LI Dan， LIU Ruiqing， CUI Xiaoyu，et al. Co-culture of bacteria and microalgae for treatment of high concentration biogas slurry［J］. Journal of Water Process Engineering，2021，41：102014. doi:10.1016/j.jwpe.2021.102014
[47]	ZHOU Xudong， JIANG Xincheng， GAO Shan，et al. Effects of oxytetracycline dihydrate and sulfamethoxazole on Microcystis aeruginosa and Chlamydomonas microsphaera ［J］. Journal of Oceanology and Limnology，2021，39（1）：160-172. doi:10.1007/s00343-020-9214-6
[48]	LI Ruying， GAO Huixin， ZHAO Qia，et al. Interaction of microalgal-bacterial symbiosis systems with tetracycline and norfloxacin and simultaneous removal of nitrogen and antibiotics in river water［J］. Journal of Water Process Engineering，2024，64：105643.
[49]	ZHANG Mingchen， STEINMAN A D， XUE Qingju，et al. Effects of erythromycin and sulfamethoxazole on microcystis aeruginosa：Cytotoxic endpoints，production and release of microcystin-LR［J］. Journal of Hazardous Materials，2020，399：123021. doi:10.1016/j.jhazmat.2020.123021
[50]	WU Shuai， ZHANG Jingmiao， XIA Ao，et al. Microalgae cultivation for antibiotic oxytetracycline wastewater treatment［J］. Environmental Research，2022，214：113850. doi:10.1016/j.envres.2022.113850
[51]	CHEN Shan， LI Jiayuan， FENG Wenbo，et al. Biochemical responses of the freshwater microalga Dictyosphaerium sp. upon exposure to three sulfonamides［J］. Journal of Environmental Sciences，2020，97：141-148.
[52]	WANG Yue， LI Jinghua， LEI Yao，et al. Bioremediation of sulfonamides by a microalgae-bacteria consortium： Analysis of pollutants removal efficiency，cellular composition，and bacterial community［J］. Bioresource Technology，2022，351：126964. doi:10.1016/j.biortech.2022.126964
[53]	方淑霞，王大力，朱丽华，等. 抗生素对微生物的联合与低剂量毒性研究进展［J］. 生态毒理学报，2015，10（2）：69-75.
	FANG Shuxia， WANG Dali， ZHU Lihua，et al. Progress in researches on toxicity of antibiotics in low dose and mixture exposure to microorganisms［J］. Asian Journal of Ecotoxicology，2015，10（2）：69-75.
[54]	LIU Wenhao， HUANG Wenli， CAO Zhenhua，et al. Microalgae simultaneously promote antibiotic removal and antibiotic resistance genes/bacteria attenuation in algal-bacterial granular sludge system［J］. Journal of Hazardous Materials，2022，438：129286. doi:10.1016/j.jhazmat.2022.129286
[55]	ZAMBRANO J， GARCÍA-ENCINA P A， HERNÁNDEZ F，et al. Removal of a mixture of veterinary medicinal products by adsorption onto a Scenedesmus almeriensis microalgae-bacteria consortium［J］. Journal of Water Process Engineering，2021，43：102226.
[56]	HOM-DIAZ A， JAÉN-GIL A， RODRIGUEZ-MOZAZ S，et al. Insights into removal of antibiotics by selected microalgae（Chlamydomonas reinhardtii，Chlorella sorokiniana，Dunaliella tertiolecta and Pseudokirchneriella subcapitata）［J］. Algal Research，2022，61：102560. doi:10.1016/j.algal.2021.102560
[57]	LONG Shengxing， HAMILTON P B， WANG Chaonan，et al. Bioadsorption，bioaccumulation and biodegradation of antibiotics by algae and their association with algal physiological state and antibiotic physicochemical properties［J］. Journal of Hazardous Materials，2024，468：133787. doi:10.1016/j.jhazmat.2024.133787
[58]	TIAN Yajun， ZOU Jinru， FENG Li，et al. Chlorella vulgaris enhance the photodegradation of chlortetracycline in aqueous solution via extracellular organic matters（EOMs）：Role of triplet state EOMs［J］. Water Research，2019，149：35-41. doi:10.1016/j.watres.2018.10.076
[59]	AHMAD W， CHANDRA JOSHI H， KUMAR S. Algae mediated photodegradation of fluroquinolone antibiotic：Ofloxacin［J］. Current Research in Green and Sustainable Chemistry，2022，5：100269. doi:10.1016/j.crgsc.2022.100269
[60]	WEI Lianxue， LI Haixiao， LU Jinfeng. Algae-induced photodegradation of antibiotics：A review［J］. Environmental Pollution，2021，272：115589.
[61]	BAI Xiaoyan， LIANG Wanyi， SUN Jian，et al. Enhanced production of microalgae-originated photosensitizer by integrating photosynthetic electrons extraction and antibiotic induction towards photocatalytic degradation of antibiotic：A novel complementary treatment process for antibiotic removal from effluent of conventional biological wastewater treatment［J］. Journal of Environmental Management，2022，308：114527.
[62]	XIE Peng， CHEN Chuan， ZHANG Chaofan，et al. Revealing the role of adsorption in ciprofloxacin and sulfadiazine elimination routes in microalgae［J］. Water Research，2020，172：115475. doi:10.1016/j.watres.2020.115475
[63]	PI Yongrui， LI Yan， JIA Wenpeng，et al. Enhancing removal performance of ciprofloxacin hydrochloride by Chlorella vulgaris-bacteria consortium：Insights of microbial responses and stoichiometry［J］. Journal of Hazardous Materials，2025，494：138780.
[64]	JI Xiyan， JIANG Mengqi， ZHANG Jibiao，et al. The interactions of algae-bacteria symbiotic system and its effects on nutrients removal from synthetic wastewater［J］. Bioresource Technology，2018，247：44-50. doi:10.1016/j.biortech.2017.09.074
[65]	许翔健，郭李恒，许超，等. 混培养系统中菌藻共生关系及其对污水处理效果的影响［C］//第二届全国水处理与回用学术会议论文集. 2018：148-148.
	XU Jianxiang， GUO Liheng， XU Chao，et al. The interactions of algal-bacterial symbiotic system and its effects on wastewater treatment［C］// Proceedings of the 2nd National Conference on Water Treatment and Reuse. 2018：148-148.
[66]	王锌针，张哲，罗娜，等. 藻菌共生体处理猪场沼液的参数优化研究［J］.工业水处理，2024，44（1）：96-102.
	WANG Zizhen， ZHANG Zhe， LUO Na，et al. Optimization of parameters for treatment of livestock farming wastewater by algal-bacterial symbiosis［J］. Industrial Water Treatment， 2024，44（1）：96-102.
[67]	YUAN Hao， ZHANG Xinru， JIANG Zeyi，et al. Effect of light spectra on microalgal biofilm：Cell growth，photosynthetic property，and main organic composition［J］. Renewable Energy，2020，157：83-89. doi:10.1016/j.renene.2020.04.109
[68]	高静思，朱佳，董文艺. 光照对我国常见藻类的影响机制及其应用［J］. 环境工程，2019，37（5）：111-116.
	GAO Jingsi， ZHU Jia， DONG Wenyi. Influence mechanism of light on common algae and its application［J］. Environmental Engineering，2019，37（5）：111-116.
[69]	李盈盈，周璐，荣宏伟，等. 光照强度对菌藻共生系统处理海产养殖废水的性能影响及微生物群落变化［J］. 净水技术，2023，42（8）：117-130.
	LI Yingying， ZHOU Lu， RONG Hongwei，et al. Effect of light intensity on performance of bacteria-algae symbiosis system for mariculture wastewater treatment and variation of microflora［J］. Water Purification Technology，2023，42（8）：117-130.
[70]	CERÓN GARCı́A M C， SÁNCHEZ MIRÓN A， FERNÁNDEZ SEVILLA J M，et al. Mixotrophic growth of the microalga Phaeodactylum tricornutum influence of different nitrogen and organic carbon sources on productivity and biomass composition［J］. Process Biochemistry，2005，40（1）：297-305. doi:10.1016/j.procbio.2004.01.016
[71]	SFORZA E， SIMIONATO D， GIACOMETTI G M，et al. Adjusted light and dark cycles can optimize photosynthetic efficiency in algae growing in photobioreactors［J］. PLoS One，2012，7（6）：e38975.
[72]	ATTA M， IDRIS A， BUKHARI A，et al. Intensity of blue LED light：A potential stimulus for biomass and lipid content in fresh water microalgae Chlorella vulgaris ［J］. Bioresource Technology，2013，148：373-378.
[73]	YANG Mingzhu， QIU Shuang， WANG Lingfeng，et al. Effect of short-term light irradiation with varying energy densities on the activities of nitrifiers in wastewater［J］. Water Research，2022，216：118291.
[74]	ZHANG Chaofan， CHEN Xi， HAN Meina，et al. Revealing the role of microalgae-bacteria niche for boosting wastewater treatment and energy reclamation in response to temperature［J］. Environmental Science and Ecotechnology，2023，14：100230.
[75]	ZHU Xiaoyu， ZHANG Huirong， CHEN Zhixuan，et al. Electrochemical fingerprinting of cephalosporin antibiotics and its applications for investigations of hydrolysis behavior［J］. Chemosphere，2023，315：137725.
[76]	SRINIVASAN P， SARMAH A K. Dissipation of sulfamethoxazole in pasture soils as affected by soil and environmental factors［J］. Science of the Total Environment，2014，479：284-291. doi:10.1016/j.scitotenv.2014.02.014
[77]	欧阳峥嵘，温小斌，耿亚红，等. 光照强度、温度、pH、盐度对小球藻（Chlorella）光合作用的影响［J］. 武汉植物学研究，2010，28（1）：49-55.
	OUYANG Zhengrong， WEN Xiaobin， GENG Yahong，et al. The effects of light intensities，temperatures，pH and salinities on photosynthesis of Chlorella ［J］. Journal of Wuhan Botanical Research，2010，28（1）：49-55.
[78]	GUO Ning， ZHANG Hengyi， WANG Lin，et al. Metagenomic insights into the influence of pH on antibiotic removal and antibiotic resistance during nitritation：Regulations on functional genus and genes［J］. Environmental Research，2024，261：119689. doi:10.1016/j.envres.2024.119689
[79]	RONG Hongwei， LI Yingying， WANG Jingyin，et al. Towards advanced mariculture wastewater treatment by bacterial-algal symbiosis system with different bacteria and algae inoculation ratios［J］. Journal of Water Process Engineering，2023，53：103826.
[80]	PERALES-VELA H V， GARCÍA R V， GÓMEZ-JUÁREZ E A，et al. Streptomycin affects the growth and photochemical activity of the alga Chlorella vulgaris ［J］. Ecotoxicology and Environmental Safety，2016，132：311-317.
[81]	WANG Yue， HE Yuanyuan， LI Xiaoqiang，et al. Enhanced biodegradation of chlortetracycline via a microalgae-bacteria consortium［J］. Bioresource Technology，2022，343：126149.
[82]	RAMBALDO L， ÁVILA H， ESCOLÀ CASAS M，et al. Assessment of a novel microalgae-cork based technology for removing antibiotics，pesticides and nitrates from groundwater［J］. Chemosphere，2022，301：134777. doi:10.1016/j.chemosphere.2022.134777
[83]	才金玲，冯辰辰，倪国倩，等. 微藻采收技术的研究进展［J］. 微生物学通报，2020，47（8）：2571-2581.
	CAI Jinling， FENG Chenchen， NI Guoqian，et al. Progress in microalgae harvesting technology［J］. Microbiology China，2020，47（8）：2571-2581.
[84]	SONG Xiangru，JO C， HAN Lujie，et al. Recent advance in microbial fuel cell reactor configuration and coupling technologies for removal of antibiotic pollutants［J］. Current Opinion in Electrochemistry，2022，31：100833.
[85]	XUE Wendan， LI Fengxiang， ZHOU Qixing. Degradation mechanisms of sulfamethoxazole and its induction of bacterial community changes and antibiotic resistance genes in a microbial fuel cell［J］. Bioresource Technology，2019，289：121632. doi:10.1016/j.biortech.2019.121632
[86]	SUN Jian， XU Wenjing， YUAN Yong，et al. Bioelectrical power generation coupled with high-strength nitrogen removal using a photo-bioelectrochemical fuel cell under oxytetracycline stress［J］. Electrochimica Acta，2019，299：500-508. doi:10.1016/j.electacta.2019.01.036
[87]	INIESTA-LÓPEZ E， FERNÁNDEZ A H， GÓMEZ J M，et al. Transforming waste management：Converting pig slurry into clean energy and biomass through integrated MFC-microalgae systems［J］. Journal of Water Process Engineering，2025，69：106815.
[88]	LIU Yanhua， WANG Zhizhi， YAN Kun，et al. A new disposal method for systematically processing of ceftazidime：The intimate coupling UV/algae-algae treatment［J］. Chemical Engineering Journal，2017，314：152-159. doi:10.1016/j.cej.2016.12.110
[89]	LI Chenguang， TIAN Qian， ZHANG Yanlei，et al. Sequential combination of photocatalysis and microalgae technology for promoting the degradation and detoxification of typical antibiotics［J］. Water Research，2022，210：117985. doi:10.1016/j.watres.2021.117985
[90]	CHEN Shan， YUAN Mingzhe， FENG Wenbo，et al. Catalytic degradation mechanism of sulfamethazine via photosynergy of monoclinic BiVO₄ and microalgae under visible-light irradiation［J］. Water Research，2020，185：116220. doi:10.1016/j.watres.2020.116220
[91]	ZHANG Biao， BIAN Yixuan， CHEN Junsheng，et al. Nitrogen reclamation from aquaculture wastewater as potential fish feed additives via bacterial and algal-bacterial granular sludge systems［J］. Bioresource Technology Reports，2023，24：101609. doi:10.1016/j.biteb.2023.101609
[92]	XIONG Wei， WANG Shaojie， JIN Yu，et al. Insights into nitrogen and phosphorus metabolic mechanisms of algal-bacterial aerobic granular sludge via metagenomics：Performance，microbial community and functional genes［J］. Bioresource Technology，2023，369：128442.
[93]	WANG Shulian， JI Bin， ZHANG Meng，et al. Tetracycline-induced decoupling of symbiosis in microalgal-bacterial granular sludge［J］. Environmental Research，2021，197：111095. doi:10.1016/j.envres.2021.111095
[94]	TANG Lan， ZHUANG Chuanyan， QI Peng，et al. Unraveling stress responses of microalgal-bacterial granular sludge when treating ciprofloxacin-laden wastewater［J］. Journal of Hazardous Materials，2025，491：137811.
[95]	ESCOLÀ CASAS M， PASTOR-LÓPEZ E J， RODRÍGUEZ-ESPELTA Y，et al. Simultaneous veterinary antibiotics reduction and biomass production from pig slurry by microalgae co-immobilization in moving bed biofilm reactors［J］. Environmental Technology & Innovation，2024，35：103677. doi:10.1016/j.eti.2024.103677

藻菌共生系统					光照			其他环境条件			废水类型	目标抗生素		去除情况		参考文献
藻	菌	生长状态	藻菌比例	投加量	光源	强度	光暗比	振荡	温度/℃	pH	废水类型	种类	质量浓度/ （mg·L^-1）	去除率/%	途径	参考文献
斜生栅藻	湖泊底泥	悬浮	1∶1	0.02 g/L	LED白光	4 000 Lx	12 h∶12 h	振荡	25±2		养殖废水	CIP	40 160	96.10±0.07 38.6±2.0		〔6〕
斜生栅藻	粪产碱菌	菌固定化	1∶2				14 h∶10 h	定时搅拌	25	7.1~7.2	模拟废水	TC	10 50	93.87 77.18	水解，生物降解，生物吸附	〔7〕
斜生栅藻为主	共生细菌	藻菌共固定			人工光源				随季节变化	7.4~7.5	污染地下水	CIP	33.5±20.9	100	生物降解，光降解，吸附	〔8〕
												ENR	20±0.6	100
												OFL	77±19	100
												SA	64.7±0.5	100
												SDZ	23.4±6.4	100
												SMZ	78.11±11.80	100
												SMT	10.2±1.1	5±7
												SMX	157.2±48.0	100
												SPY	3.4±0.8	51±35
												STZ	22.7±9.4	83±24
无绿藻	铜绿假单胞菌	悬浮	1∶1 （体积比）	1% （体积分数）				180 r/min	20~40	4~9	畜禽养殖废水	AMX	5~50	>80	生物降解	〔9〕
网球藻属为主	假单胞菌属为主	悬浮		0.15 g/L		（95±5） μmol/（m²·s）			25±1	6.8~7.5	模拟废水	OTC	1 100	100 99.2	生物降解	〔10〕
麦克属微藻	共生细菌	悬浮				3 000 Lx	14 h∶8 h	定期曝气	24±1			SMX	0.1 1	97.3±4.9 62.7±2.8	生物降解为主，吸附次之	〔11〕
阿尔默栅藻	共生细菌	悬浮		1 g/L	LED白光	12.62 mW/cm²	12 h∶12 h	200 r/min	25	8	模拟废水	TC	1	1.03	水解	〔12〕
														6.83	光降解
														14.29	生物降解
														77.78	生物吸附
												CIP	0.5	1.39	水解
														7.29	光降解
														69.33	生物吸附
												SDZ	0.1	2.94	水解
														3.94	光降解
														9.94	生物吸附
														35.76	生物降解
												SMX	0.02	5.01	生物降解
普通小球藻	活性污泥玫瑰色拟青霉地衣芽孢杆菌藻内生菌	悬浮		116.24±6.39 mg/L	红蓝光，强度比 5∶5	200 μmol/（m²·s）	12 h∶12 h		25±0.5		养猪废水	TC	2	98.77±1.05		〔13〕
												OTC	2	93.74±5.06
												CIP	2	62.44±5.58
												NOR	2	55.07±4.97
												SDM	2	70.39±6.03
												SMX	2	67.46±6.25
普通小球藻	厌氧污泥	悬浮			LED白光				30±1		水产养殖废水	FLO	0.5~5	>80	生物降解	〔14〕
普通小球藻	枯草芽孢杆菌	藻菌共固定化	1∶1（体积比）	1 g∶2.39 mL（质量体积比）	LED白光	（200±22） μmol/（m²·s）	24 h∶0		25±2	7.31~7.45	模拟制药废水	LIN	82	98.54	生物降解	〔15〕
普通小球藻	硝化污泥	生物膜				（3 000± 250） Lx	12 h∶12 h	全混	25±2		合成废水	SMX	0.2	44.6~75.8 （长期运行）		〔16〕
索罗金小球藻	泛养副球菌	悬浮			冷光灯	4 000 Lx	24 h∶0	150 r/min	28		养猪废水	TCH	0.5 2	70.58 93.33		〔17〕
蛋白核小球藻	活性污泥	悬浮	5∶1	0.2 g/L		4 000 Lx	12 h∶12 h		25±1		模拟生活污水	LEV	0.1 1	33.62 57.20	生物降解	〔18〕
蛋白核小球藻	厌氧污泥	悬浮，分隔两腔室	7∶4	2.37 g/L		6 000 Lx	12 h∶12 h	60 r/min	252		模拟海水养殖废水	SMX	0.1 1	73.5 58.5	生物降解	〔19〕
巨球藻	天然废水细菌	藻固定化		藻100 mg/L	LED白光	3 500 Lx	12 h∶12 h	连续扰动	25±1		城市污水	SMX	4.51~5.67 μg/L	48.59~74.25 （长期运行）		〔20〕
自然环境中的藻菌共生系统		悬浮		115 mg/L	LED白光	（235±22） μmol/（m²·s）	24 h∶0		室温	8.54	污水处理厂出水	TMP	0.05	15.93±1.82	生物降解	〔21〕
														1.03±0.07	生物吸附
														0.98±0.03	生物蓄积
														6.64±0.77	非生物去除
												SMX	0.05	43.36±0.75	生物降解
												SMX	0.05	4.98±0.32	非生物去除

藻菌共生系统					光照			其他环境条件			废水类型	目标抗生素		去除情况		参考文献
藻	菌	生长状态	藻菌比例	投加量	光源	强度	光暗比	振荡	温度/℃	pH	废水类型	种类	质量浓度/ （mg·L^-1）	去除率/%	途径	参考文献
斜生栅藻	湖泊底泥	悬浮	1∶1	0.02 g/L	LED白光	4 000 Lx	12 h∶12 h	振荡	25±2		养殖废水	CIP	40 160	96.10±0.07 38.6±2.0		〔6〕
斜生栅藻	粪产碱菌	菌固定化	1∶2				14 h∶10 h	定时搅拌	25	7.1~7.2	模拟废水	TC	10 50	93.87 77.18	水解，生物降解，生物吸附	〔7〕
斜生栅藻为主	共生细菌	藻菌共固定			人工光源				随季节变化	7.4~7.5	污染地下水	CIP	33.5±20.9	100	生物降解，光降解，吸附	〔8〕
												ENR	20±0.6	100
												OFL	77±19	100
												SA	64.7±0.5	100
												SDZ	23.4±6.4	100
												SMZ	78.11±11.80	100
												SMT	10.2±1.1	5±7
												SMX	157.2±48.0	100
												SPY	3.4±0.8	51±35
												STZ	22.7±9.4	83±24
无绿藻	铜绿假单胞菌	悬浮	1∶1 （体积比）	1% （体积分数）				180 r/min	20~40	4~9	畜禽养殖废水	AMX	5~50	>80	生物降解	〔9〕
网球藻属为主	假单胞菌属为主	悬浮		0.15 g/L		（95±5） μmol/（m²·s）			25±1	6.8~7.5	模拟废水	OTC	1 100	100 99.2	生物降解	〔10〕
麦克属微藻	共生细菌	悬浮				3 000 Lx	14 h∶8 h	定期曝气	24±1			SMX	0.1 1	97.3±4.9 62.7±2.8	生物降解为主，吸附次之	〔11〕
阿尔默栅藻	共生细菌	悬浮		1 g/L	LED白光	12.62 mW/cm²	12 h∶12 h	200 r/min	25	8	模拟废水	TC	1	1.03	水解	〔12〕
														6.83	光降解
														14.29	生物降解
														77.78	生物吸附
												CIP	0.5	1.39	水解
														7.29	光降解
														69.33	生物吸附
												SDZ	0.1	2.94	水解
														3.94	光降解
														9.94	生物吸附
														35.76	生物降解
												SMX	0.02	5.01	生物降解
普通小球藻	活性污泥玫瑰色拟青霉地衣芽孢杆菌藻内生菌	悬浮		116.24±6.39 mg/L	红蓝光，强度比 5∶5	200 μmol/（m²·s）	12 h∶12 h		25±0.5		养猪废水	TC	2	98.77±1.05		〔13〕
												OTC	2	93.74±5.06
												CIP	2	62.44±5.58
												NOR	2	55.07±4.97
												SDM	2	70.39±6.03
												SMX	2	67.46±6.25
普通小球藻	厌氧污泥	悬浮			LED白光				30±1		水产养殖废水	FLO	0.5~5	>80	生物降解	〔14〕
普通小球藻	枯草芽孢杆菌	藻菌共固定化	1∶1（体积比）	1 g∶2.39 mL（质量体积比）	LED白光	（200±22） μmol/（m²·s）	24 h∶0		25±2	7.31~7.45	模拟制药废水	LIN	82	98.54	生物降解	〔15〕
普通小球藻	硝化污泥	生物膜				（3 000± 250） Lx	12 h∶12 h	全混	25±2		合成废水	SMX	0.2	44.6~75.8 （长期运行）		〔16〕
索罗金小球藻	泛养副球菌	悬浮			冷光灯	4 000 Lx	24 h∶0	150 r/min	28		养猪废水	TCH	0.5 2	70.58 93.33		〔17〕
蛋白核小球藻	活性污泥	悬浮	5∶1	0.2 g/L		4 000 Lx	12 h∶12 h		25±1		模拟生活污水	LEV	0.1 1	33.62 57.20	生物降解	〔18〕
蛋白核小球藻	厌氧污泥	悬浮，分隔两腔室	7∶4	2.37 g/L		6 000 Lx	12 h∶12 h	60 r/min	252		模拟海水养殖废水	SMX	0.1 1	73.5 58.5	生物降解	〔19〕
巨球藻	天然废水细菌	藻固定化		藻100 mg/L	LED白光	3 500 Lx	12 h∶12 h	连续扰动	25±1		城市污水	SMX	4.51~5.67 μg/L	48.59~74.25 （长期运行）		〔20〕
自然环境中的藻菌共生系统		悬浮		115 mg/L	LED白光	（235±22） μmol/（m²·s）	24 h∶0		室温	8.54	污水处理厂出水	TMP	0.05	15.93±1.82	生物降解	〔21〕
														1.03±0.07	生物吸附
														0.98±0.03	生物蓄积
														6.64±0.77	非生物去除
												SMX	0.05	43.36±0.75	生物降解
												SMX	0.05	4.98±0.32	非生物去除

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